Vitamin A, Cancer Treatment and Prevention: The New Role of Cellular Retinol Binding Proteins

Figure 3

Immunohistochemical expression of CRBP-1 in normal and neoplastic female reproductive system tissues. (a) CRBP-1 is strongly expressed in normal endocervical epithelial cells, (b) proliferative and (c) atrophic endometrial glandular cells. (d) Well-differentiated (G1) endometrial carcinoma cells show strong and diffuse CRBP-1 positive cells compared to (e) lower and focal CRBP-1 expression in moderately (G2) carcinoma. In the ovary, CRBP-1 is not expressed in (f) mucinous, (g) serous borderline, and (h) well-differentiated (G3) serous carcinoma. Original magnification: (a), (c)–(h) 100x; (b) 200x.

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