Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays

Figure 2

Confocal images for retracted WB clots treated with CAPE. (a) Image of normal retracted WB without CAPE treatment. The figure demonstrates fibrin binding the RBCs in the retracted WB clot (control); the white arrow is pointing to the RBCs. (b) 3.75 mM CAPE; the fibrin is reduced on the RBCs. (c) 7.50 mM CAPE; the fibrin level is less than in 3.75 mM CAPE sample. (d, e, and f) 15.00, 22.50, and 30.00 mM CAPE, respectively; the fibrin is completely absent, leaving behind only RBCs that appear red in color (63x, magnification bar = 20 μm).

(a) Retracted

(b) 3.75 mM

(c) 7.5 mM

(d) 15 mM

(e) 22.5 mM

(f) 30 mM