MicroRNA and mRNA Features of Malignant Pleural Mesothelioma and Benign Asbestos-Related Pleural Effusion

Figure 3

Selected pathways and genes by an integrated analysis using overexpressed mRNA (microarray) and targets genes of underexpressed miR. Yellow depicts targets of underexpressed miR and blue depicts overexpressed genes by microarray. Green depicts overexpressed genes that are also targets of underexpressed miR. There were 232 genes in the 8 pathways. Only 32 genes that participated in more than 1 pathway are shown. Only one of two pathways related to NOTCH signaling was included in creating this figure. MAPK1, TGFBR2, EP300, CDC42, MET, IGF1R, and SMAD2 participate in 3 or more pathways. MET and CCNE2 mRNAs are overexpressed and are targets of underexpressed miR.