Review Article

Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer

Figure 1

Kaplan-Meier analysis of gene expression data from 690 patients with ER-negative breast tumours shows that 10-year recurrence-free survival is significantly worse if tissue IGFBP-3 is high (red) compared to low (black), and this difference is even greater if expression of both IGFBP3 and EGFR is high. HR: hazard ratio.