Substance P Receptor Antagonism: A Potential Novel Treatment Option for Viral-Myocarditis

Figure 6

Effect of aprepitant or fasudil treatment on heart functional changes in viral-myocarditis. (a) End systolic diameter (ESD), (b) fractional shortening, and (c) peak aortic flow velocity were determined by ECHO and Doppler in hearts of EMCV uninfected mice and infected mice, with and without aprepitant or fasudil treatment. Results are expressed as the mean ± SEM (, uninfected versus infected, †, infected, with versus without aprepitant pretreatment, ¥, uninfected versus infected, with fasudil pretreatment and, §, uninfected versus infected, with fasudil posttreatment, ( for all ANOVA) (–8)).

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(b)

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