Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort
Table 1
Selected demographic and clinical characteristics of participants at the time of AV-45 PET scan.
HC ()
EMCI ()
LMCI ()
AD ()
Age (years)
74.51 (5.74)
71.43 (7.28)
73.03 (7.49)
74.87 (9.05)
Women
94 (49%)
95 (44%)
62 (41%)
17 (38%)
Education (years)
16.53 (2.64)
15.95 (2.66)
16.32 (2.90)
15.67 (2.70)
APOE e4 allele present
54 (28%)
87 (40%)
78 (51%)
33 (73%)
CDR-SOB
0.03 (0.13)
1.22 (0.72)
1.73 (0.94)
4.36 (1.64)
Mini mental status examination
29.07 (1.20)
28.39 (1.46)
27.25 (1.77)
22.93 (2.08)
Logical memory immediate recall (WMS-R)
14.46 (3.08)
10.96 (2.77)
7.32 (3.06)
4.40 (2.52)
Logical memory delayed recall (WMS-R)
13.55 (3.27)
8.90 (1.72)
4.22 (2.75)
2.02 (2.17)
Normalized SUVR of cingulate amyloid burden
1.211 (0.21)
1.273 (0.23)
1.274 (0.27)
1.48 (0.24)
AD: Alzheimer’s disease; CDR–SOB: clinical dementia rating-sum of boxes; EMCI: early mild cognitive impairment; HC: healthy control; LMCI: late mild cognitive impairment; PET: positron emission tomography; WMS-R: Wechsler Memory Scale-Revised. Data are shown in the format of “number (%)” or “mean (SD).”
