Research Article
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort
Table 2
Results of sample (: eight SNP-SNP interactions associated with cingulate amyloid burden. The Bonferroni corrected values (<0.05) and of the SNP-SNP interaction term are shown in bold.
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Age + Sex + Dx: percent of variance in cingulate amyloid burden explained by age, gender, and diagnosis. bAPOE: percent of additional variance in cingulate amyloid burden explained by the APOE genotype after accounting for age, gender, and diagnosis. cBCHE: percent of additional variance in cingulate amyloid burden explained by the BCHE SNP after accounting for age, gender, diagnosis, and APOE genotype. dSNP1 + SNP2: percent of additional variance in cingulate amyloid burden explained by the combined main effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, APOE genotype, and the BCHE SNP. eSNP1 SNP2: percent of additional variance in cingulate amyloid burden explained by the interaction effect of SNP1 and SNP2 after accounting for age, gender, diagnosis, APOE genotype, the BCHE SNP, SNP1, and SNP2. Nearest gene proximal to the SNP. |