The ABCC6 Transporter as a Paradigm for Networking from an Orphan Disease to Complex Disorders

Figure 1

ABCC6 topology model. ABCC6 is a transmembrane transporter, consisting of 3 transmembrane domains (TMD0–2) and 2 linker regions: the latter are built up by the 2 ABC motifs with the 2 nucleotide-binding folds (NBF1-2). Furthermore, there are 2 glycosylation sites in the extracellular part of the transporter.