Systematic Analysis of the Associations between Adverse Drug Reactions and Pathways

Figure 2

The AP network. (a) In the AP network, the blue circles correspond to ADRs, and the red triangles correspond to biological pathways. An edge is placed between an ADR node and a pathway node when drugs that induced the ADR are significantly enriched in the set of drugs that perturbed the pathway. (b) The distribution of ADR-pathway interactions in the random AP networks. The -axis denotes the edge number, and the -axis is the frequency of the edge numbers in random AP networks (the edge number of the real AP network is labeled in red arrow). ((c), (d)) The distributions of the average degrees of ADR and pathway nodes in the random AP networks. The red arrows denote the average degrees of ADR and pathway nodes in real AP network, respectively.

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