Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

Figure 1

Cell viability of mouse-derived 32D cells transfected with the BCR-ABL1 oncogene sensitive to imatinib (filled circles) or cells with primary resistance to imatinib caused by the Y253H mutation in BCR-ABL1 (filed squares) or acquired imatinib resistance (empty squares). Viability was evaluated by MTT assay. Each point is mean of six independent experiments; error bars represent SEM but in some points they were smaller than the symbol radius.