Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

<div>Basal mRNA expression of mitochondrial cytochrome b (<i>MT-CYB</i>) and NADH dehydrogenase 3 (<i>MT-ND3</i>) genes determined by real-time PCR in mouse-derived 32D BCR-ABL1+ cells sensitive to imatinib (S) and cells with resistance caused by the Y253H mutation in the<i> BCR-ABL1</i> gene (253) or acquired imatinib resistance (AR). The expression of either gene was normalized to the mouse<i><i>β</i>-actin</i> gene;<i> n</i> = 3 for each cell line; number above bars shows significant<i> p</i> values for comparison between pairs connected by brackets.</div>

BioMed Research International

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Figure 2: Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib 

Figure 2 | Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib 