Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer
Table 4
Gene-environment interaction between the polymorphisms and smoking status.
Interaction
for interaction
OR (95% CI)
NFKB1 smoking status
0.31
NFKB1 -94 ins/ins nonsmokers
Ref.
—
NFKB1 -94 ins/del smokers
1.01 (0.76–1.33)
0.96
NFKB1 -94 del/del smokers
0.74 (0.50–1.10)
0.14
NFKBIA smoking status
0.71
NFKBIA -826CC nonsmokers
Ref.
—
NFKBIA -826CT smokers
1.13 (0.80–1.60)
0.49
NFKBIA -826TT smokers
1.41 (0.35–5.66)
0.63
COX-2 smoking status
<0.01
COX-2 (-1195GG) nonsmokers
Ref.
—
COX-2 (-1195GA) smokers
1.29 (0.98–1.69)
0.07
COX-2 (-1195AA) smokers
1.76 (1.28–2.41)
<0.01
COX-1 smoking status
0.13
COX-1 (50CC) nonsmokers
Ref.
—
COX-1 (50CT) smokers
1.46 (0.92–2.32)
0.11
COX-1 (50TT) smokers
2.38 (0.57–10.00)
0.24
PPARG smoking status
0.23
PPARG Pro/Pro nonsmokers
Ref.
—
PPARG Pro/Ala smokers
0.92 (0.50–1.68)
0.11
PPARG Ala/Ala smokers
N/A
N/A
There were two factors involved (polymorphism and smoking status) in each testing; hence, significance is assumed at after application of Bonferroni correction.
