Research Article
Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer
Table 5
Combination of polymorphisms and prostate cancer risk.
| | Interaction | for interaction | OR (95% CI) | |
| | NFKB1 NFKBIA polymorphisms | 0.03 | | | | NFKB1 -94 ins/ins NFKBIA -826CC | | Ref. | — | | NFKB1 -94 ins/del NFKBIA -826CT | | 0.99 (0.71–1.38) | 0.94 | | NFKB1 -94 del/del NFKBIA -826TT | | 3.16 (0.81–12.28) | 0.10 | | NFKB1 -94 ins/del NFKBIA -826CT | | 0.65 (0.39–1.07) | 0.09 | | NFKB1 -94 del/del NFKBIA -826TT | | N/A | — |
| | COX-2 (-1195GG) COX-1 (50CC) | 0.02 | Ref. | — | | COX-2 (-1195GA) COX-1 (50CT) | | 1.34 (0.87–2.07) | 0.19 | | COX-2 (-1195AA) COX-1 (50CT) | | 1.83 (1.06–3.17) | 0.03 | | COX-2 (-1195GA) COX-1 (50TT) | | N/A | — | | COX-2 (-1195AA) COX-1 (50TT) | | 1.47 (0.30–7.29) | 0.64 |
|
|
There were two polymorphisms involved in each testing; hence, significance is assumed at after application of Bonferroni correction.
|
