Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis

Figure 2

Elevation of Shh expression in mice infected with Angiostrongylus cantonensis. (a) Western blotting showing significant increases in the levels of Shh from day 7 to day 28 after infection (, ). (b) An increased Shh expression was demonstrated by immunofluorescence staining of brain sections from an infected mouse on day 28. (c) No apparent changes were observed in a mouse without the infection on the same day (GFAP: green; Shh: red; colocalization of GFAP and Shh: yellow).

(a)  

(b)

(c)