Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway

Figure 2

LMWC-induced changes in histology. Light micrographs of rat kidney sections were stained with hematoxylin and eosin. (a) Histology of kidney tissue in the control group. (b) Necrotic tubules and desquamation were apparent after treatment with 150 mg/kg/day GM for 6 days. (c) Treatment of GN rats with 165 mg/kg/day LMWC for 13 days improved histology. (d) Treatment of GN rats with 825 mg/kg/day LMWC for 13 days significantly improved histology. (e) Treatment of GN rats with 100 mg/kg/day metformin for 13 days significantly improved histology.

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