Improvement of Endurance of DMD Animal Model Using Natural Polyphenols

Figure 2

Endurance test. Histogram representing endurance test of treated mice. (a) Each symbol corresponds to a single animal performance; endurance test was repeated once per day for 30 days for each mouse. The average value corresponds to the total amount of time measured during the tests for 30 days. As demonstrated by the average number of hours run mdx-treated mice increased significantly their performance versus untreated mice, even if this value was far from that of C57Bl mice (a). (b) Graph showed relative motor capacity of mice (percentage normalized to baseline) at 4 different time points (each week for 30 days). (c) Graph showed the absolute value of T4 of graph in (b) (that is the average time to exhaustion at T4 (30 days)) that was higher in mdx treated mice related to untreated ones. Tetanic force of TA (d) and DIA (e) was performed in treated and untreated mdx mice.

(a)

(b)

(c)

(d)

(e)