Improvement of Endurance of DMD Animal Model Using Natural Polyphenols

Figure 3

DHE staining and quantification. (a) DHE staining on muscle sections from TA and QA of mdx mice. DHE staining revealed anion superoxide production at nuclear level. Arrows indicated DHE staining on both cellular infiltrate and fibers myonuclei. (b) We quantified DHE staining intensity on muscle section. Histogram showed a reduced production of oxidative damage as measured by DHE staining in TA muscle of mdx-treated mice versus untreated ones (,05). (c) Graph showed the correlation between DHE staining intensity and CD11b+ infiltrate (per field). The mean and SD for each category are plotted. ProAbe treatment reduced CD11b+ infiltrates more than DHE intensity (as shown by right position of untreated mice versus left position of treated mice).

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