Serial Patterns of Ovarian Cancer Biomarkers in a Prediagnosis Longitudinal Dataset

Table 2

Areas under the ROC curve for the six individual markers with 95% confidence intervals using the last measurement for all subjects (47 case samples, 179 control samples), the last measurement for all subjects within 6 months of cancer diagnosis (42 case samples, 179 control samples), and the last measurement for all subjects at greater than 6 months before diagnosis (42 case samples, 179 control samples).

Marker	Last measurement (average 0.29 years before diagnosis)		Last measurement ≤6 months before diagnosis		Last measurement >6 months before diagnosis
	AUC	95% CI	AUC	95% CI	AUC	95% CI
CA125	0.957	0.918–0.997	0.976	0.952–0.999	0.763	0.685–0.842
Glycodelin	0.888	0.828–0.948	0.883	0.816–0.949	0.713	0.62–0.806
HE4	0.881	0.81–0.952	0.869	0.792–0.945	0.653	0.551–0.755
Mesothelin	0.712	0.618–0.807	0.729	0.632–0.825	0.539	0.438–0.64
MMP7	0.589	0.484–0.693	0.625	0.517–0.733	0.554	0.448–0.66
CYFRA 21-1	0.71	0.622–0.797	0.72	0.634–0.805	0.492	0.406–0.61
CA125 + HE4	0.965	0.935–0.995	0.98	0.961–0.999	0.77	0.693–0.848
CA125 + glycodelin + HE4	0.967	0.938–0.996	0.982	0.966–0.998	0.789	0.714–0.865