Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis

Figure 2

TNFα-blocker administration decreases inflammatory response in CIA. DBA1/J mice with established CIA (day 25 after immunization) were intraperitoneally injected with PBS (closed columns) or anti-TNFα (2 mg/week, open columns) once per week. Systemic and local expression of inflammatory mediators was assayed in protein extracts from joints of hind limbs (a) and sera (b) isolated at day 40 after immunization; to 4 mice/group. versus controls.

(a)

(b)