Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis

Figure 3

Morphological features of articular lesion in CIA model in DBA1/J mice. (a): (A) Unaffected joint. (B) Pannus. (C) Synovial hyperplasia with chronic inflammatory infiltrate. (D) Hyaline cartilage surrounded by spindle-shaped mesenchymal cells. (E) Bone destruction mediated by osteoclast activation. (F) Partial destruction of articular cartilage. Bar 100 μm (Masson’s trichrome, original magnification ×20). (b): (A) Limb without joint lesions. (B) Partial response to etanercept with persistence of pannus (E-group). (C) Intense joint lesion with pannus and chronic inflammatory infiltrate in articular cavity and partial destruction of bone tissue (C-group) (Masson’s trichrome, original magnification ×4).

(a)

(b)