Osteoarticular Expression of Musashi-1 in an Experimental Model of Arthritis

Figure 4

Immunohistochemical expression of Musashi-1 (Msi1) in CIA model in DBA1/J mice. (a): (A) Scant Msi1 expression was detected in chondrocytes, synoviocytes, and inflammatory cells in articular or periarticular lesions or in medullary bone tissue in joints with no morphological changes. (B) Nuclear expression of Msi1 in mesenchymal cells, articular capsule, and articular cartilage. Bar 200 μm (micropolymer peroxidase-based method, original magnification ×4). (b): (A) Very scant nuclear Msi1 expression in joint with no morphological changes (E-group). (B), (C), and (D) Moderate Msi1 expression in mesenchymal cells, articular capsule, and articular cartilage in CIA-lesioned joints (C-group) (micropolymer peroxidase-based method, original magnification ×20).

(a)

(b)