Identification of Gene Biomarkers for Distinguishing Small-Cell Lung Cancer from Non-Small-Cell Lung Cancer Using a Network-Based Approach

Figure 3

Examples of gene modules and genes that can distinguish SCLC from NSCLC. (a) shows a module that is upregulated in SCLC, while (b) shows a module with only four genes that is downregulated in SCLC. The ROC curve of the two modules is shown at the right of the figure. The color of each gene inside the module represents the expression pattern of this gene between a cancer subtype and the normal lung tissues, with red indicating that it is upregulated in cancer, while blue indicating that it is downregulated. The edge color of each interaction inside the module represents the coexpression information in the corresponding cancer subtypes, with orange indicating positive coexpression while green indicating negative coexpression.

(a)

(b)