Factors Influencing the Eicosanoids Synthesis In Vivo

Figure 1

Simplified diagram of eicosanoid synthesis. The α-linolenic and linoleic acids are substrates for the synthesis of AA, EPA, and DHA which are added at the sn-2 position to lysophospholipids (via the Lands cycle) or to glycerophospholipids (via the Kennedy pathway). The AAs, EPAs, and DHAs that were released from glycerophospholipids by the PLA(2) are substrates for COX, LOX, cytochrome (CYP), and other enzymes involved in the eicosanoid synthesis.