Brain Parenchymal Fraction: A Relatively Simple MRI Measure to Clinically Distinguish ALS Phenotypes

Table 3

Clinical characteristics of ALS patients with FTD.

Patient	Gender	Age (yr)	Site of onset	Features of FTD
				Extent	Domain affected
					(at time of MRI)
1	F	67	Speech	Mild	bv., ex., l.
2	F	75	UE	Mild	ex., l.
3	F	60	Speech	Mod.	bv., ex.
4	F	58	Speech	Mod.	bv., l.
5	F	60	Cognitive	Mod.	bv.
6	M	63	Speech	Severe	bv., l. (PNFA)
7	M	75	Cognitive	Severe	bv., mem.
8	F	53	Speech	Severe	bv., l.
9	F	52	Speech	Severe	g.
10	M	59	Cognitive	Severe	g.
11	M	87	UE, LE	Severe	g.
12	F	69	Cognitive	Severe	bv., l.
13	F	68	Cognitive	Severe	bv., ex.
14	F	67	LE	Severe	ex., l. (sem.), mem.
15	F	65	Cognitive	Severe	bv., l.
16	F	63	LE	Severe	bv., ex., l.
17	F	77	Speech	Severe	bv., ex., l.
18	M	78	LE	Severe	g.

bv. = behavior; Cog. = cognitive; ex. = executive; g. = global (bv. + ex. + l. + mem. present); l. = language; LE = lower extremity; mem. = memory; PNFA = progressive nonfluent aphasia; sem. = semantic; and UE = upper extremity.