Preoperative RAS Mutational Analysis Is of Great Value in Predicting Follicular Variant of Papillary Thyroid Carcinoma

Table 5

Molecular genotype according to the cytologic diagnosis of 187 follicular variants of papillary thyroid carcinoma.

	Number of BRAF V600E; mutated cases (%)	Number of BRAF K601E; mutated cases (%)	Number of RAS; mutated cases (%)	Number of nonmutated cases (%)
Nondiagnostic ()	0	0	0	1 (100)
Benign ()	0 (0.0)	0 (0.0)	1 (12.5)	7 (87.5)
AUS/FLUS ()	19 (21.3)	10 (11.2)	41 (46.1)	19 (21.3)
FN/SFN ()	0	0	6 (54.5)	5 (45.5)
SMC ()	14 (42.4)	1 (3.0)	7 (21.2)	11 (33.3)
Malignant ()	24 (53.3)	0	9 (20.0)	12 (26.7)
Total ()	57 (30.5)	11 (5.9)	64 (34.2)	55 (29.4)

AUS/FLUS indicates atypia of undetermined significance or follicular lesion of undetermined significance; FN/SFN: follicular neoplasm or suspicious for follicular neoplasm; SMC: suspicious for malignant cell.