Salivary Desmoglein Enzyme-Linked Immunosorbent Assay for Diagnosis of Pemphigus Vulgaris: A Noninvasive Alternative Test to Serum Assessment

Table 5

Serum anti-Dsg 1, serum anti-Dsg3, and salivary antidesmoglein 3 ELISA main diagnostic outcomes using the manufacturer’s suggested cut-off value of 20 RU/mL.

	Serum anti-Dsg 1 ELISA	Serum anti-Dsg 3 ELISA	Salivary anti-Dsg 3 ELISA
True positive	62	83	63
True negative	176	176	178
False positive	4	4	2
False negative	24	3	23
Sensitivity	72.09%	96.51%	73.26%
Specificity	97.78%	97.78%	98.89%
Positive predictive values	0.94	0.95	0.97
Negative predictive values	0.88	0.98	0.89
Test accuracy	0.89	0.97	0.91
Positive likelihood ratio	32.44	43.33	65.93
Negative likelihood ratio	0.29	0.04	0.27
Diagnostic odds ratio	113.67	1217.33	243.78
Cohen’s kappa coefficient	0.89	0.97	0.90