PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis

Figure 1

PLK-1 polypeptide sequence of human. PLK-1 gene encodes a polypeptide sequences with 603 amino acids. PLK-1 consists of two types of domains (1) the conserved ser/thr N-terminal kinase domain (53-305aa). There are three ATP-binding cassettes in kinase domain: Lys82, Glu131, and Asp194, responsible for ATP-binding and T-loop (Thr210). (2) Two C-terminal polo-box domain (411-592aa), three key residues at PBD: Trp414, His538, and Lys540 are responsible for phosphopeptide binding.