Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity

Figure 3

A restricted cubic spline model was used to estimate the hazard ratio as a function of age. The restricted cubic spline for non-Hispanic white ethnicity exhibits an increased risk of islet autoimmunity (IA) early on that then becomes protective in the older ages (a). The restricted cubic spline for a 5-year difference in maternal age exhibits a slightly elevated risk of IA in early childhood that becomes protective in adolescence (b). The x-axis represents age in years and the y-axis represents the hazard ratio on the log scale. The solid line represents the hazard ratio and the dashed lines represent the pointwise 95% confidence bands.

(a)

(b)