Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Figure 4

Cumulative degradation of silica (▪) and release of nimodipine (●) from implant B to dissolution medium (50 mM Tris buffer, pH = 7.4 at 37°C) in in sink dissolution.