Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

Figure 3

TNF-α increases Iba1 immunoreactivity in the dentate gyrus. TNF-α (250 μg/kg, i.p.) caused a strong upregulation of the microglial activation marker Iba1 in the hippocampal dentate gyrus at 24 h after administration. Representative images (10x) (a) and image quantifications of per group (b). Graph is plotted as mean + SEM. Data were analyzed by ANOVA followed by independent samples -test. compared to vehicle.

(a)

(b)