Peripheral Administration of Tumor Necrosis Factor-Alpha Induces Neuroinflammation and Sickness but Not Depressive-Like Behavior in Mice

Figure 5

Peripheral TNF-α administration reduces total fluid intake (a) but does not induce clear anhedonia (b) in the sucrose preference test. Separate groups of naive animals were injected i.p. with TNF-α and tested in the SPT at either 6 h or 24 h. Dashed line indicates chance level for sucrose preference. Graphs are plotted as mean + SEM ( per group). Data were analyzed by ANOVA followed by independent samples -test. ; compared to 0 μg/kg TNF-α at the same time point.

(a)

(b)