Review Article
Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas
Table 1
Summary of expression pattern of some miRNAs studied in MB and their potential clinical [
40–
43].
| | miRNA | Expression
pattern | Potential
clinical | Cellular
targets | Cellular
function |
| | miRNA-let7g | UP | POOR | ND | ND |
| | miRNA-9 | DOWN | ND | Trkc | Increase apoptosis
low proliferation |
| | miRNA-10b | UP | ND | ND | ERBB2 overexpression |
| | miRNA-17/92 | UP | POOR | ND | SHH Pathway |
| | miRNA-19a | UP | POOR | ND | Associated with
high risk |
| | miRNA-21 | UP | ND | Pdcd4 | Metastatic process |
| | miRNA-23b | UP | BETTER | ND | WNT pathway |
| | miRNA-25 | UP | ND | P57 | Tumor suppressive function |
| | miRNA-30b/miRNA-30d | UP | ND | ND | 8q24.22-q24.23
amplification |
| | miRNA-31 | DOWN | ND | ND | Associated with
high risk |
| | miRNA-34a | DOWN | ND | MAGE-A
DII1
Notch1
Notch2 | Increase apoptosis
Increase cell cycle
Decrease cell proliferation
Increasing senescence |
| | miRNA-96 | DOWN/UP | ND/ND | AKT/ND | Cell cycle G0/G1,
G2/ND |
| | miRNA-100 | UP | POOR | ND | Targets predicted in carcinogenesis |
| | miRNA-106b | UP | POOR | ND | Anaplastic histology |
| | miRNA-124a | DOWN | POOR | CDK6
SLC16A1 | Cell cycle
Glycolysis |
| | miRNA-125a | DOWN | ND | Trkc | Increase apoptosis
low proliferation |
| | miRNA-125b | DOWN | POOR | Smo | SHH Pathway |
| | miRNA-125p | DOWN | ND | Smo
Gli1 | SHH Pathway |
| | miRNA-128a | DOWN/UP | BETTER/ND | Bmi-1/ND | Targeting oncogene
Bmi-1/associated MYC |
| | miRNA-128b | UP | ND | ND | Associated with MYC |
| | miRNA-129 | DOWN | ND | ND | ND |
| | miRNA-135a/miRNA-135b | UP | ND | ND | ERBB2 overexpression |
| | miRNA-148a | UP | BETTER | ND | WNT pathway |
| | miRNA-153 | DOWN | ND | ND | ERBB2 overexpression |
| | miRNA-181b | UP | ND | ND | Associated MYC overexpression |
| | miRNA-182 | DOWN/UP | ND/ND | AKT/ND | Increase cell cycle G0 and G2,
Decrease cell proliferation and migration/WNT pathway |
| | miRNA-183~96~ | DOWN/UP | ND/POOR | AKT/ND | Increase cell cycle G0 and G2,
Decrease cell/ND proliferation and migration |
| | miRNA-186 | DOWN | ND | MYC | Decrease cell proliferation |
| | miRNA-191 | UP | POOR | ND | ND |
| | miRNA-193a | UP | BETTER | ND | WNT pathway |
| | miRNA-199b-5p | UP | BETTER | HES1 | Notch signaling |
| | miRNA-214 | UP | POOR | SUFU | SHH pathway |
| | miRNA-218 | DOWN | POOR | EGFR
Bcl-2 | ND |
| | miRNA-224/452 | UP | POOR | ND | WNT pathway |
| | miRNA-324-5p | DOWN | POOR | Gli1 | SHH pathway |
| | miRNA-326 | DOWN | POOR | ND | ND |
| | miRNA-365 | UP | BETTER | ND | WNT pathway |
| | miRNA-383 | DOWN | ND | PRDX3 | Increase apoptosis
Increase cell cycle G1
Decrease cell proliferation |
| | miRNA-512-2/miRNA-512-5p | DOWN | ND | MYC | Decrease cell proliferation |
| | miRNA-548d-1/miRNA-548d-2 | DOWN | ND | MYC | Decrease cell proliferation |
| | miRNA-935 | DOWN | ND | KIAA0232
SLC5A3
TBC1D9
ZFAND6 | ND |
|
|
ND, not determined.
|
