The Influence of Ghrelin on the Development of Dextran Sodium Sulfate-Induced Colitis in Rats

Table 1

Influence of dextran sodium sulfate (DSS) administered in drinking water and saline (NaCl) or ghrelin given intraperitoneally at the dose of 8 nmol/kg/dose on morphological signs of colonic damage.

	Morphological changes
	Size of lesions	Inflammatory infiltration	Depth of lesions	Fibrosis
	(0–2)	(0–3)	(0–3)	(0–3)
Control
Scoring observed in individual animals	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0
	1, 0, 0, 0, 0	0, 0, 0, 0, 0	1, 0, 0, 0, 0	0, 0, 0, 0, 0
The predominant grading	0	0	0	0
Ghrelin
Scoring observed in individual animals	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0
	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0	0, 0, 0, 0, 0
The predominant grading	0	0	0	0
DSS
Scoring observed in individual animals	1, 1, 2, 1, 2	2, 2, 3, 2, 3	1, 1, 2, 1, 1	0, 1, 2, 1, 1
	1, 2, 2, 2, 2	2, 3, 3, 2, 2	1, 1, 1, 1, 1	1, 1, 1, 1, 1
The predominant grading	1-2	2-3	1	1
DSS + Ghrelin
Scoring observed in individual animals	0, 1, 0, 0, 0	2, 3, 2, 2, 3	0, 1, 0, 0, 0	0, 0, 0, 0, 0
	1, 0, 1, 0, 0	1, 2, 3, 2, 3	1, 0, 1, 0, 0	0, 0, 1, 0, 0
The predominant grading	0	2-3	0	0