β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats

Figure 2

Effect of ACE inhibition on deposition of collagen types I and III in 2K1C hypertensive rats. Unclipped kidneys from 2K1C rats treated or not treated with lisinopril were immunostained for collagen types I and III. Representative immunofluorescence (IF) images for collagen type I of (a) sham, (b) 2K1C rats, or (c) 2K1C rats treated with lisinopril. Immunohistochemistry (IHQ) for collagen type III of (d) sham, (e) 2K1C rats, or (f) 2K1C rats treated with lisinopril. Quantification of (g) collagen type I and (h) collagen type III IHQ. Collagen types I and III immunostaining increases in 2K1C rats compared with the sham control, while the treatment with lisinopril decreases both. Scale bar = 100 μm.

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