β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats

Figure 9

Effect of pyrvinium pamoate on deposition of collagen types I and III in 2K1C hypertensive rats. Unclipped kidneys from 2K1C rats treated with pyrvinium pamoate were immunostained for collagen type I and type III. Representative images from immunofluorescence for collagen type I of (a) sham, (b) 2K1C rats, and (c) 2K1C rats treated with pyrvinium pamoate. Immunohistochemistry for collagen type III of (d) sham, (e) 2K1C rats, and (f) 2K1C rats treated with lisinopril. Quantification of (g) collagen type I IF and (h) collagen type III IHQ. The treatment with pyrvinium pamoate decreased both collagen type I and type III in the unclipped kidney from 2K1C rats compared. Scale bar = 100 μm.

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