Review Article
Design, Materials, and Mechanobiology of Biodegradable Scaffolds for Bone Tissue Engineering
Table 5
Resorption mechanisms for biomaterials for scaffolds used in bone regeneration. From Bohner [
37]
*.
| Material type | Material | Degradation mechanism |
| | Bioglass | Generally: very limited degradation through partial dissolution | | Plaster of Paris (= calcium sulphate hemihydrate, CSH) Gypsum | Dissolution |
Ceramic | Dicalcium phosphate dehydrate (= calcium sulphate dihydrate, CSD) | Dissolution and/or conversion into an apatite | Calcium carbonate | Dissolution or cell-mediated depending on the mineral phase | | Dicalcium phosphate (DCP) Octacalcium phosphate (OCP) β-Tricalcium phosphate (β-TCP) Biphasic calcium phosphate (BCP) Precipitated hydroxyapatite crystals β-Calcium pyrophosphate (β-CPP; β-Ca2P2O7) | Cell-mediated | | Sintered hydroxyapatite | Practically no degradation |
|
Metal | Magnesium (alloy) | Corrosion | Iron (alloy) | Corrosion | Tantalum, titanium | Practically no degradation |
|
Polymer | Polylactides, polyglycolides Polycaprolactone | Hydrolysis | Cellulose Hyaluronan Fibrin Collagen Chitosan | Transport to lymph nodes Hyaluronidase Plasmin Collagenase Lysozyme |
|
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Reprinted from Materials Today, with permission from Elsevier [37].
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