Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Cardiovascular and Cerebrovascular Diseases

Table 1

Overview of circulating miRNAs in various cardiovascular and cerebrovascular diseases.

Diseases type	miRNAs	Relationship	References
AMI	miR-208a	+	[28, 29, 31]
	miR-1	+	[32]
	miR-133a	+	[34]
	miR-133b	+	[35]
	miR-499	+	[36]
	miR-499-5p	+	[37]
	miR-328	+	[38]
	miR-1291, miR-663b	+	[39]
	miR-223	−	[40]
	miR-122, miR-375	−	[30]
	miR-197, miR-223,	−	[41]
	miR-126	+	[41]
HF	miRNA-423-5p	+	[43]
	miR-423-5p, miR-22, miR-320a, miR-92b	+	[44]
	miR-499	+	[45]
AF	miRNA-150	−	[46]
HCM	miR-29a	+	[47]
DCM	MiR-142-3p	−	[48]
	miR-124-5p	+	[48]
TTC	miR-1, miR-16, miR-26a, miR-133a	+	[49]
Hypertension	miR-296-5p, miR-let-7e, hcmv-miR-UL112	+	[50]
	hsa-miR-505	+	[51]
	miR-23b, miR-130a, miR-191	+	[52]
	miR-451, miR-1246	−	[52]
	miR-26a	−	[53]
	miRNA-150	−	[54]
CAD	miR-126, miR-92a, miR-17, miR-145, miR-155	−	[31]
	miR-135a	+	[56]
	miR-147	−	[56]
CAD (differentiate unstable angina from stable angina)	miR-134, miR-198, miR-370	+	[56]
CAD	miR-149	+	[57]
CAD (with restenosis)	miR-31	+	[58]
CAD	miR-133a, miR-208a	+	[31]
	miR-126, miR-17, miR-92a, miR-155	−	[31]
	miR-214	−	[59]
	miR-122, miR-370	+	[60]
Stroke	miR-124	+	[62, 63]
	miR-125b-2, miR-27a, miR-422a, miR-488, miR-627	+	[64]
	MiR-290	+	[65]
	MiR-10a, miR-182, miR-200b, miR-298	+	[66]
	hsa-miR-106b-5P, hsa-miR-4306	+	[67]
	hsa-miR-320e, hsa-miR-320d	−	[67]
	miR-124, miR-9, miR-219	−	[68]
	miR-30a, miR-126	−	[69]
	miR-122, miR-148a, let-7i, miR-19a, miR-320d, miR-4429	−	[70]
	miR-363, miR-487b	+	[70]
	miR-210	−	[71]

AMI indicates acute myocardial infarction; HF, heart failure; AF, atrial fibrillation; HCM, hypertrophic cardiomyopathy; DCM, dilated cardiomyopathy; TTC, Takotsubo cardiomyopathy; CAD, coronary artery disease.