MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes

Figure 3

Expression of miR-17-92, miR-106a-363, and miR-106b-25 clusters in old versus young adult mouse hearts. (a) The expression of miRNA guide strands with aging in the heart. Most of the 15 guide strands were upregulated with aging in the heart, where 11 guide strands were expressed in the same direction, but four guide strands (miR-18a-5p, miR-18b-5p, miR-20b-5p, and miR-363-5p) were increased in some old mice while decreased in other old mice. (b) The expression of miRNA passenger strands with aging in the heart. The expression of the eight passenger strands was complex, where only one, miR-106a-3p, was increased in all three old versus young adult mice, while seven passenger strands were increased in some old mice and decreased in other old mice.

(a)

(b)