MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes

Figure 4

The miRNA expression in response to glucose stress. The C2C12 cells (ATCC CRL-1772) were cultured in normal glucose (100 mg/dL) medium to 80% confluence and then treated with either high glucose (400 mg/dL) or low glucose (30 mg/dL) for six hours, respectively. The miR-17-92 cluster is represented by three microRNAs; the miR-106a-363 cluster is represented by two microRNAs; the miR-106b-25 cluster is represented by three microRNAs. The mircroRNAs in each of the clusters either increased or decreased in the same direction in response to the stresses. Please note that miR-27a does not belong to any of the miR-17-92-related clusters but has been included here for comparison only.