The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation

Table 1

Selectivity profiles of quinalizarin on a 140-kinase panel. Residual CK2 activity (determined at 1 M quinalizarin concentration) is expressed as a percentage of the control activity without inhibitor. Conditions are described or referenced in the experimental section. Activities <50% of control are bold typed.

Kinase	Activity %	Kinase	Activity %	Kinase	Activity %
	10	PKCa	95	TAK1	107
	42	IRAK4	95	CDK9-Cyclin T1	108
PIM3	62	HIPK3	96	RSK1	108
MLK3	63	JNK3	96	MPSK1	108
CK1δ	72	IGF-1R	96	RSK2	108
BRK	72	VEG-FR	96	DDR2	109
PLK1	75	IRAK1	97	EPH-A2	110
MST2	77	MAPKAP-K2	97	MNK1	110
MST4	78	PAK5	97	PKCγ	110
CHK2	80	IKKe	97	CHK1	111
MKK1	81	GSK3b	98	OSR1	111
TrkA	81	DYRK1A	98	JNK2	112
PKBb	81	MAPKAP-K3	98	STK33	112
CAMK1	82	MSK1	99	NEK6	112
MKK2	82	AMPK (hum)	99	IKKb	112
ABL	82	SYK	99	EIF2AK3	112
PDK1	83	PDGFRA	99	p38g MAPK	114
MAP4K3	84	LKB1	99	MKK6	114
MLK1	84	p38a MAPK	99	ZAP70	114
PIM1	85	HIPK2	99	p38b MAPK	114
FGF-R1	85	HER4	100	CSK	114
MAP4K5	86	MARK2	100	TTBK1	115
PAK6	87	TTBK2	100	Aurora A	115
TIE2	88	EPH-B2	101	TAO1	115
MNK2	88	TTK	101	MEKK1	115
SIK2	89	ULK2	101	MELK	116
MARK3	89	WNK1	101	SRPK1	117
YES1	89	ERK8	102	EPH-B3	117
GCK	90	PINK	102	PRK2	118
ERK1	90	PKCz	102	PIM2	120
TESK1	90	PAK4	102	IRR	120
PKBa	91	JAK2	102	ASK1	120
DYRK2	91	MARK4	103	p38d MAPK	120
SGK1	91	BRSK1	103	PKA	121
CK1γ2	91	PRAK	103	CDK2-Cyclin A	121
S6K1	91	RIPK2	103	Lck	122
CLK2	91	TBK1	103	HIPK1	123
SmMLCK	92	DYRK3	104	BTK	125
JNK1	92	NUAK1	104	EPH-A4	126
ULK1	92	NEK2a	105	TLK1	126
Aurora B	93	SIK3	105	MST3	126
DAPK1	93	ROCK 2	105	IR	128
ERK2	94	MINK1	105	TGFBR1	130
CAMKKb	94	ERK5	106	TSSK1	131
EF2K	94	EPH-B1	106	EPH-B4	132
BRSK2	95	PAK2	106
PKD1	95	MARK1	106
Src	95	PHK	107