Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model

<div>Effects of various formulations of ETP chemotherapy on the survival of tumor-bearing mice. The fibrosarcoma was induced by exposure to benzo(a)pyrene. The treatment of tumor-bearing animals was started at the time point when tumor size reached a volume of approximately 200 mm<sup>3</sup>. Various formulations of etoposide at the dose of 5 mg/kg were administered intraperitoneally to treat tumor-bearing mice twice weekly for three weeks. The first day of treatment was considered day zero. Free ETP versus untreated control (<i>P</i> = 0.0077); ETP-DPPC-liposomes versus free ETP (<i>P</i> = 0.2838); and ETP-Cam-liposomes versus free ETP (<i>P</i> = 0.0303).</div>

BioMed Research International

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Figure 7

Figure 7: Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model 