Review Article
Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy
Table 1
Time dependent changes in the biomarkers of oxidative stress in rodent models of epilepsy and in human epileptic patients.
(a) |
| Rat kainate model | 4 hr | 8 hr | 16 hr | 24 hr | 48 hr | 3–7 d | 3 week | Human patients | |
| GSH/GSSG ratio | | | | | | | | GSH/GSSG ratio | | Lipid peroxidation (TBA assay) | | | | | | | | Lipid peroxidation (TBA assay) | | Protein oxidation | | | | | | | | Protein oxidation | | SOD | | | | | | | | SOD | | NADPH oxidase | | | | | | | | catalase | | catalase | | | | | | | | aconitase | | aconitase | | | | | | | | DNA damage (OdG assay) | | DNA damage (OHdG assay) | | | | | | | | | |
|
|
(b) |
| Rat kindling model | 4 hr | 8 hr | 16 hr | 24 hr | 48 hr | 3–7 d | 3 week |
| GSH/GSSG ratio | | | | | | | | Lipid peroxidation (TBA assay) | | | | | | | | SOD | | | | | | | | aconitase | | | | | | | |
|
|
(c) |
| Rat Pilocarpine model | 4 hr | 8 hr | 16 hr | 24 hr | 48 hr | 3–7 d | 3 week |
| GSH/GSSG ratio | | | | | | | | Lipid peroxidation (TBA assay) | | | | | | | | SOD | | | | | | | | catalase | | | | | | | |
|
|
(d) |
| Mice kainic acid model | 4 hr | 8 hr | 16 hr | 24 hr | 48 hr | 3–7 d | 3 week |
| GSH/GSSG ratio | | | | | | | | Lipid peroxidation (TBA assay) | | | | | | | |
|
|
Rat kainate model [48–52], Rat kindling model [53–57], Rat pilocarpine model [58–60], Mouse kainate model [61–64], Human patients [65–67].
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