Evaluation of the Efficacy of a Bacteriophage in the Treatment of Pneumonia Induced by Multidrug Resistance Klebsiella pneumoniae in Mice

Figure 5

Histopathology of KP-infected lung tissue from PBS- or phage 1513-treated mice. A group of 10 mice were inoculated intranasally with 6 × 10⁷ CFU KP/mouse. Additionally, phage 1513 was administered intranasally. The mice were euthanized 24 h after infection, and lung tissues were removed as described above. (a) PBS, without K. pneumoniae; (b) K. pneumoniae, treated with PBS; (c) K. pneumoniae, treated with phage 1513 ((a1), (b1), and (c1) were amplified 40 times; (a2), (b2), and (c2) were amplified 100 times; and (a3), (b3), and (c3) were amplified 200 times).