Review Article
The Formation of Biofilms by Pseudomonas aeruginosa: A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms
Table 2
Synthetic inhibitory compounds in P. aeruginosa biofilm formation.
| Synthetic compounds (Natural compound origin) | Activities | References | QS inhibition | Biofilm inhibition(a) | Dispersion promotion | Synergistic antibiotic and/or immune defense effect |
| TAGE and CAGE (Bromoageliferin) | NC | + (24 h) | + | NC | [132] | Dihydrosventrin (Sventrin) | NC | + (24 h) | + | NC | [133] | N-(4-bromo-phenylacetanoyl)-l-HSL; N-(indole-3-butanoyl)-L-HSL (AHLs) | + AHLs antagonist (las system) | + (24 h) | NC | NC | [97] | 3-oxo-C12-cyclohexanone (AHLs) | + AHLs antagonist (las system) | + (24 h) | NC | NC | [98] | C10-cyclopentylamide (AHLs) | + (lasI and rhlA) | + (24 h) | NC | NC | [99] | Furanone C-30 and C-56 (Furanone) | + (las, rhl systems) | + (24 h) | | | [55, 100, 101] | S-phenyl-L-cysteine sulfoxide (Cysteine sulfoxide alliin) | + (las, rhl systems) | + (24 h) | NC | NC |
[148] | Diphenyl disulfide (Disulfide derivatives of the alliinase mediated reactions) | + las system | + (24 h) | NC | NC | Azythromycin (Erythromycin) | + (gacA, las and rhl systems) | + (72 h) | + | +(1) | [103, 108, 109] |
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+: yes; −: no; NC: not communicated. At subinhibitory concentration. (a)Experiment duration. (1)Aminoglycosides.
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