Research Article
The Role of FGFR1 Gene Amplification as a Poor Prognostic Factor in Squamous Cell Lung Cancer: A Meta-Analysis of Published Data
Table 1
Characteristics of the studies included in the meta-analysis.
| Author | Year | Race | NP | Positive (number) | Positive (%) | Histology | Stage | Test method | HR estimate | Cutoff | Result |
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Seo et al. [29] | 2014 | Japan | 369 | 33 | 8.9 | NSCLC | I–III | FISH | HR + CI | ≥6.2 | NS | Cihoric et al. [26] | 2014 | Switzerland | 329 | 41 | 12.5 | NSCLC | I-II | FISH | HR + CI | ≥2 | Poor | Toschi et al. [30] | 2014 | America | 445 | 74 | 16.6 | NSCLC | I–III | FISH | Survival curves | ≥4 | NS | Russell et al. [31] | 2014 | Australia | 352 | 50 | 14.2 | NSCLC | I–IV | FISH | HR + CI | ≥2.0 | NS | Gadgeel et al. [22] | 2013 | America | 345 | 12 | 3.5 | NSCLC | I–IV | qPCR | HR + CI | >3.5 | Poor | Craddock et al. [38] | 2013 | Canada | 121 | 11 | 9.1 | SQCC | I–IV | FISH | HR + CI | ≥5 | NS | Tran et al. [24] | 2013 | Australia | 264 | 37 | 14.0 | NSCLC | I–IV | CISH | Survival curves | ≥2.0 | Favor | Kim et al. [25] | 2013 | Korean | 262 | 34 | 13.0 | SQCC | I–III | FISH | HR + CI | ≥9 | Poor | Heist et al. [40] | 2012 | America | 226 | 37 | 16.4 | SQCC | I–IV | FISH | Survival curves | ≥2.2 | NS | Kohler et al. [28] | 2012 | Germany | 133 | 14 | 10.5 | SQCC | — | FISH | Survival curves | ≥4 | NS | Sasaki et al. [23] | 2012 | Japan | 100 | 32 | 32.0 | NSCLC | I–IV | qPCR | Survival curves | >4 | NS | Weiss et al. [27] | 2010 | Germany | 232 | 16 | 6.9 | NSCLC | I–III | FISH | Survival curves | >9 | NS |
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NP, number of patients; HR, hazard ratio; CI, confidence interval; NSCLC, non-small cell lung cancer; SQCC, squamous cell lung cancer; FISH, fluorescence in situ hybridization; qPCR, quantitative polymerase chain reaction; CISH, chromogenic in situ hybridization; NS, nonsignificant.
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