Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade

Figure 2

Representative pressure-volume loops from SU_M and RNU_M at 4 weeks. At baseline, the pressure-volume loop is in red. During occlusion of the inferior vena cava, the right ventricular end-diastolic volume decreases, shifting the following loops (green) toward the left. Similarly the right ventricular end-systolic pressure decreases, shifting the loops to the bottom. The linear end-systolic relationship is represented in blue, linking all end-systolic points from the successive pressure-volume loops during transient occlusion of the inferior vena cava. The slope of this line defines the end-systolic elastance of the ventricle ().

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