Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common Tissue

Figure 2

The TSN is a bipartite network. (a) The circles and rectangles in the network represent TFs and subpathways, respectively. A pair of TFs and a subpathway were connected by an edge if the set of target genes of TF was significantly enriched in the corresponding subpathway. Node size was proportional to the degree of the node. Edges were colored according to the enrichment significance () of associations between TF target genes and subpathways. (b) Component size distributions of TFs and subpathways in the TSN and random network. The actual size of the real network giant component was smaller than that of the 1000 randomly shuffled TFs (521 versus 554.9630, experiential ). (c) Bar plot of degree of TF distribution in the TSN. (d) Bar plot of degree of distribution of subpathways in TSN.

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