Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis
Table 1
Baseline characteristics of patients at ICU admission ( = 117, day 0).
Variables
Survivors
Nonsurvivors
value
()
()
Age, yr
63.0 ± 16.6
62.3 ± 15.9
0.832
Male (%)
42 (64.6)
31 (59.6)
0.579
BMI, kg/m2
22.6 ± 4.1
22.9 ± 3.8
0.754
Length of ICU stay, days
11.0 , 20.5
12.5 [3.3, 23.8]
0.695
Severe sepsis
17 (26.2)
2 (3.8)
0.001
Septic shock
48 (73.8)
50 (96.2)
0.001
APACHE II score
18.3 ± 6.0
20.0 ± 5.0
0.082
SOFA score
6.9 ± 3.1
8.6 ± 3.7
0.008
Infection site
0.014
Lung
45 (69.2)
49 (94.2)
Urinary tract
5 (7.7)
—
Abdomen
11 (16.9)
3 (5.8)
Others
4 (6.1)
—
Underlying diseases
Diabetes mellitus
21 (32.3)
9 (17.3)
0.065
Chronic lung disease†
10 (15.4)
14 (26.9)
0.125
Chronic renal disease
11 (16.9)
9 (17.3)
0.956
Hypertension
27 (41.5)
19 (36.5)
0.582
Heart failure
9 (13.8)
6 (11.5)
0.711
Coronary artery disease
6 (9.2)
6 (11.5)
0.683
Chronic liver disease
4 (6.2)
6 (11.5)
0.301
Clinical parameters
Hemoglobin, g/dL
10.2 ± 2.2
9.6 ± 2.1
0.151
Platelets, 103/mm3
204.9 ± 157.7
177.6 ± 145.6
0.338
Albumin, g/dL
2.7 ± 0.7
2.6 ± 0.6
0.185
Blood urea nitrogen, mg/dL
32.3 ± 27.2
30.9 ± 25.2
0.776
Creatine, mg/dL
2.1 ± 2.1
1.7 ± 1.8
0.224
CRP, mg/dL
15.2 ± 11.1
19.6 ± 14.0
0.068
Lipids
Cholesterol, mg/dL
106.0 [78.0, 132.0]
84.5 [57.5, 129.5]
0.196
Triglyceride, mg/dL
100.0 [66.5, 188.5]
81.0 [61.8, 113.5]
0.011
High-density lipoprotein, mg/dL
21.0 [13.0, 30.5]
21.0 [9.0, 27.0]
0.411
Low-density lipoprotein, mg/dL
46.0 [29.5, 69.5]
39.0 [22.0, 65.0]
0.414
Free fatty acid, µEq/L
487.5 [287.0, 742.8]
441.0 [222.0, 570.8]
0.026
Lipoprotein A, mg/dL
7.0 [3.0, 23.1]
6.1 [2.7, 19.0]
0.242
Data are presented as numbers (percentages). Data are presented as the median [interquartile range]. †Chronic lung disease includes asthma, COPD, and structural lung diseases, such as bronchiectasis and interstitial lung disease. ICU, intensive care unit; BMI, body mass index; APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment.
