Research Article
iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma
Table 1
Description and comparison of clinical and laboratory characteristics of the study subjects.
| Characteristic | Discovery samples by iTRAQ | Validation samples by ELISA | RCC () | Control () | RCC () | Control () |
| Age (years) | 54.80 ± 13.32 | 52.80 ± 9.13 | 53.10 ± 13.33 | 55.63 ± 13.98 | Gender (male/female) | 7/3 | 7/3 | 18/12 | 16/14 | BMI | 22.86 ± 2.57 | 22.55 ± 2.55 | 21.78 ± 2.83 | 22.16 ± 3.02 | Hypertension | 4 (40%) | 2 (20%) | 6 (20%) | 4 (13.3%) | Diabetes mellitus | 2 (20%) | 1 (10%) | 5 (16.7%) | 3 (10%) | Smoking | 3 (30%) | 3 (30%) | 7 (23.3%) | 6 (20%) | Pathological stage | | | | | pT1 | 10 (100%) | | 16 (53.3%) | | pT2 | | | 11 (36.7%) | | pT3 | | | 2 (6.7%) | | pT4 | | | 1 (3.3%) | | M0 | 10 (100%) | | 28 (93.3%) | | M1 | | | 2 (6.7%) | | Fuhrman grades | | | | | G1-2 | 10 (100%) | | 21 (70%) | | G3-4 | | | 9 (30%) | | Histological subtype | | | | | Clear-cell | 10 (100%) | | 23 (76.7%) | | Papillary | | | 3 (10%) | | Chromophobe | | | 4 (13.3%) | |
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Data are expressed as (%), or mean ± SD. RCC: renal cell carcinoma.
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