Glutamine May Repress the Weak LPS and Enhance the Strong Heat Shock Induction of Monocyte and Lymphocyte HSP72 Proteins but May Not Modulate the HSP72 mRNA in Patients with Sepsis or Trauma

Figure 3

PBMCs’ HSP72 mRNA was significantly induced by HS within 2 hours compared to the LPS induction (a). Dashed lines with values indicate differences between the two induction modalities in each group. Baseline and various treatment models did not differ among H, SIRS, and SS groups in either HS or LPS induction modes. On the contrary, 24 hr supernatant cytokines were induced by LPS and not by HS, especially among critically ill patients (b). Dashed lines with values indicate differences between the two induction modes in each group. Cytokines differed among groups in the LPS induction mode. Differences are indicated between groups by , SIRS versus H, , SS versus H, and , SIRS versus SS. Induced mRNA was positively related to the intracellular HSP72 proteins (). In contrast it was negatively related () to IL-6, IL-8, IL-10, TNF, and MCP-1 (c).

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